Discussion: Causative Agent

نویسنده

  • Warren A. Andiman
چکیده

Since stock cultures of organisms that have been passaged many times in the laboratory may undergo changes in their pathogenicity, concern was expressed as to whether antimicrobial sensitivity tests performed in vitro accurately reflect the clinical responses one might expect in treating patients. Dr. Feeley believed that various strains of the Lyme disease spirochete are stable in vitro, but could offer no assurance that there was a perfect correlation between in vitro tests and clinical responses. He stated that because some spirochetes contain plasmids associated with virulence or antimicrobial resistance it might be best, in some circumstances, to use strains that were recently isolated to assure that there is no plasmid loss. It was pointed out that the imperfect correlation between in vitro tests of susceptibility of the Lyme disease spirochete to erythromycin and its possible shortcomings in treating patients should encourage physicians to depend first on their cumulative clinical experience in treating patients. In vitro susceptibility tests should be used only as a general guide to the clinician as to what antimicrobials might be useful in treating patients.

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عنوان ژورنال:
  • The Yale Journal of Biology and Medicine

دوره 57  شماره 

صفحات  -

تاریخ انتشار 1984